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The great questions of philosophy, the mind–body problem and the nature of knowledge, were also the questions that drove early developments in the pathways to modern psychology. This is especially true of biological or physiological psychology. Wilhelm Wundt, who founded experimental psychology, titled his major work Foundations of Physiological Psychology (1874/1908). William James, the other major figure in the development of modern psychology, devoted a third of his influential text Principles of Psychology (1890) to the brain and nervous system. Both Wundt and James studied medicine and philosophy, and both considered themselves physiologists. Their goal was not to reduce psychology to physiology but rather to apply the scientific methods of physiology to the study of the mind. The other driving force in early biological psychology was the study of the brain and nervous system.

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